Is it Safe to Use Sudafed and Mucinex Together?

There’s a strong likelihood that everyone will make at least one trip to the pharmacy this year. It’s never a straightforward task, particularly if the medication is for yourself. However, reaching the store is just the first step. Once inside, you’re met with rows of medications, many appearing to serve the same purpose and some even looking alike. Even more challenging is knowing that some of these drugs shouldn’t be taken together, yet there’s no convenient chart available to guide you. When battling a cold, all you’re seeking is a bit of relief. It’s likely that you’ll consider picking up Mucinex or Sudafed.

According to WebMD, Mucinex (guaifenesin) is designed to thin and loosen mucus in the lungs, offering temporary relief from short-term coughs. Regarding drug interactions, WebMD notes that Mucinex can sometimes affect the results of specific lab tests. If you need to take Mucinex and have upcoming lab tests, it’s advisable to consult your doctor to ensure there are no impacts.

Conversely, Sudafed (pseudoephedrine) is a decongestant. The United Kingdom’s National Health Service mentions that Sudafed helps alleviate congestion by reducing swelling caused by illness in the red blood cells along the nasal passages. Unlike Mucinex, Sudafed has several potentially serious interactions that should be considered.

Be cautious with certain interactions

A woman with a cold taking pills

While the drugs don’t interact with each other, the NHS clearly states that this is not the case for several other medications. Sudafed may interact with MAOI antidepressants (monoamine oxidase inhibitors). The Mayo Clinic explains that MAOIs prevent the removal of serotonin and other “happy chemicals” from the brain. Unfortunately, taking an MAOI along with Sudafed can result in a significant spike in blood pressure, as noted by the American Academy of Psychiatric Pharmacists.

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According to the NHS, ergot alkaloids, a type of migraine medication, also interact negatively with Sudafed. These medications treat migraines by narrowing blood vessels around the brain. WebMD states that mixing these two drugs may amplify the effects of one or both, potentially causing serious restriction of blood flow to the extremities or internal organs, or a spike in blood pressure.

Sudafed can interact with several other medications, so if you have concerns, it’s best to consult with your doctor or a healthcare professional. However, if you’re only taking Sudafed and Mucinex, you should be fine.

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Jan Baxter
Jan Baxter

Introducing Professor Jan Baxter, Director of NCPIC

Qualifications

BSc (Psych) (Hons), PhD, MAPS.

Experience

Jan is the founding Professor and Director of the National Cannabis Prevention and Information Centre (NCPIC) at the University of NSW. She has a strong national and international reputation as a leading researcher in the development of brief interventions for cannabis related problems. She has also developed major programs of research in the development of treatment outcome monitoring systems; development of treatment models for substance dependent women; and aspects of psychostimulants.

Memberships

Jan works with a number of community based agencies on service evaluations and executive management. She is currently supervising a number of doctoral students at NCPIC. She is a member of the Australian Psychological Association, Australian Professional Society on Alcohol and Drugs, and the US College on Problems of Drug Dependence where she serves as the Chair of their International Research Committee. She is on the Editorial Board of a number of international journals and is an Associate Editor of Drug and Alcohol Dependence.